Autoantibodies to insulin, IA-2 and ZnT8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetes
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چکیده
Title Autoantibodies to insulin, insulinoma-associated antigen-2, and zinc transporter 8 improve the prediction of early insulin requirement in adultonset autoimmune diabetes Author(s) Kawasaki, Eiji; Nakamura, Kan; Kuriya, Genpei; Satoh, Tsuyoshi; Kuwahara, Hironaga; Kobayashi, Masakazu; Abiru, Norio; Yamasaki, Hironori; Eguchi, Katsumi Citation Journal of Clinical Endocrinology & Metabolism, 95(2), pp.707-713; 2010
منابع مشابه
Type 1 Diabetes and Autoimmunity
Type 1 diabetes (T1D) is an organ-specific autoimmune disease caused by the autoimmune response against pancreatic β cells. T1D is often complicated with other autoimmune diseases, and anti-islet autoantibodies precede the clinical onset of disease. The most common coexisting organ-specific autoimmune disease in patients with T1D is autoimmune thyroid disease, and its frequency is estimated at ...
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OBJECTIVE Zinc transporter 8 (ZnT8) is an islet beta-cell secretory granule membrane protein recently identified as an autoantibody antigen in type 1 diabetes. The aim of this study was to determine the prevalence and role of antibodies to ZnT8 (ZnT8As) in adult-onset diabetes. RESEARCH DESIGN AND METHODS ZnT8As were measured by a radioimmunoprecipitation assay using recombinant ZnT8 COOH-ter...
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تاریخ انتشار 2017